|
|
|
|
||
        |  |
 |
|
|
 |
|
 |
||||||||
|
||||||||||
|
|
|
|
|||||||
|
||||||||||
|
Graphical contents list • MISCELLANEOUS PDF (514 K) | |||
|
Novel epicatechin derivatives with antioxidant activity modulate interleukin-1β release in lipopolysaccharide-stimulated human blood • SHORT COMMUNICATION Montserrat Mitjans, Verónica Martínez, Jaime del Campo, Celia Abajo, Carles Lozano, Josep Lluís Torres and Maria Pilar Vinardell SummaryPlus | Full Text + Links | PDF (269 K) | |||
|
Fragmentation of Golgi membranes by norrisolide and designed analogues • SHORT COMMUNICATION Thomas P. Brady, Erin K. Wallace, Sun Hee Kim, Gianni Guizzunti, Vivek Malhotra and Emmanuel A. Theodorakis SummaryPlus | Full Text + Links | PDF (422 K) | |||
|
Application of the Stille coupling reaction to the synthesis of C2-substituted endo–exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) • SHORT COMMUNICATION Arnaud C. Tiberghien, David Hagan, Philip W. Howard and David E. Thurston SummaryPlus | Full Text + Links | PDF (272 K) | |||
|
1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor • SHORT COMMUNICATION R. Richard Goehring, John F.W. Whitehead, K. Brown, Khondaker Islam, Xin Wen, Xiaoming Zhou, Zhengming Chen, Kenneth J. Valenzano, Wendy S. Miller, Shen Shan and Donald J. Kyle SummaryPlus | Full Text + Links | PDF (299 K) | |||
|
Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones • SHORT COMMUNICATION Jyh-Haur Chern, Chung-Chi Lee, Chih-Shiang Chang, Yen-Chun Lee, Chia-Liang Tai, Ying-Ting Lin, Kak-Shan Shia, Ching-Yin Lee and Shin-Ru Shih SummaryPlus | Full Text + Links | PDF (286 K) | |||
|
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor • SHORT COMMUNICATION Nan-Horng Lin, Le Wang, Xilu Wang, Gary T. Wang, Jerry Cohen, Wen-Zhen Gu, Haiying Zhang, Saul H. Rosenberg and Hing L. Sham SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Synthesis and cytotoxic activity of novel derivatives of 4′-demethylepipodophyllotoxin • SHORT COMMUNICATION Shi-Wu Chen, Xuan Tian and Yong-Qiang Tu SummaryPlus | Full Text + Links | PDF (269 K) | |||
|
5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP • SHORT COMMUNICATION Richard Sulsky, Jeffrey A. Robl, Scott A. Biller, Thomas W. Harrity, John Wetterau, Fergal Connolly, Kern Jolibois and Lori Kunselman SummaryPlus | Full Text + Links | PDF (269 K) | |||
|
Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor • SHORT COMMUNICATION Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson and Nicholas D.P. Cosford SummaryPlus | Full Text + Links | PDF (260 K) | |||
|
4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists • SHORT COMMUNICATION Jean-Marie Receveur, Emelie Bjurling, Trond Ulven, Paul Brian Little, Pia K. Nørregaard and Thomas Högberg SummaryPlus | Full Text + Links | PDF (300 K) | |||
|
Development of a polyvalent assay system for lead identification • SHORT COMMUNICATION Frank Lovering, Yvonne Angell, Yan-Ling Zhang and Kristie Bridges SummaryPlus | Full Text + Links | PDF (340 K) | |||
|
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid • SHORT COMMUNICATION Ian Stansfield, Salvatore Avolio, Stefania Colarusso, Nadia Gennari, Frank Narjes, Barbara Pacini, Simona Ponzi and Steven Harper SummaryPlus | Full Text + Links | PDF (279 K) | |||
|
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction • SHORT COMMUNICATION Kenneth M. Boy, Jason M. Guernon, Sing-Yuen Sit, Kai Xie, Piyasena Hewawasam, Christopher G. Boissard, Steven I. Dworetzky, Joanne Natale, Valentin K. Gribkoff, Nicholas Lodge and John E. Starrett et al. SummaryPlus | Full Text + Links | PDF (272 K) | |||
|
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand • SHORT COMMUNICATION Mark A. Matulenko, Bruce Surber, Leimin Fan, Teodozyi Kolasa, Masaki Nakane, Marc A. Terranova, Marie E. Uchic, Loan N. Miller, Renjie Chang, Diana L. Donnelly-Roberts et al. SummaryPlus | Full Text + Links | PDF (265 K) | |||
|
A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A • SHORT COMMUNICATION Kevin Tidgewell, Wayne W. Harding, Mark Schmidt, Kenneth G. Holden, Daryl J. Murry and Thomas E. Prisinzano SummaryPlus | Full Text + Links | PDF (267 K) | |||
|
Benzothiophene and naphthalene derived constrained SERMs • SHORT COMMUNICATION Owen B. Wallace, Henry U. Bryant, Pamela K. Shetler, Mary D. Adrian and Andrew G. Geiser SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group • SHORT COMMUNICATION Yasuo Takano, Futoshi Shiga, Jun Asano, Wataru Hori, Tsuyosi Anraku and Takashi Uno SummaryPlus | Full Text + Links | PDF (282 K) | |||
|
Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I) • SHORT COMMUNICATION Aida Chircorian and Amy M. Barrios SummaryPlus | Full Text + Links | PDF (276 K) | |||
|
Benzopyranones with retro-amide side chains as (inhibitory) β-lactamase substrates • SHORT COMMUNICATION S.A. Adediran, D. Cabaret, J.-F. Lohier, M. Wakselman and R.F. Pratt SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors • SHORT COMMUNICATION Joseph Dudash, Jr., Xiaoyan Zhang, Roxanne E. Zeck, Sigmond G. Johnson, Geoffrey G. Cox, Bruce R. Conway, Philip J. Rybczynski and Keith T. Demarest SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp. • SHORT COMMUNICATION Rémy C. Lemoine, Tomasz W. Glinka, William J. Watkins, Aesop Cho, Jessie Yang, Nadeem Iqbal, Rajeshwar Singh, Deidre Madsen, Karen Lolans, Olga Lomovskaya et al. SummaryPlus | Full Text + Links | PDF (294 K) | |||
|
Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives • SHORT COMMUNICATION William J. Watkins, Rémy C. Lemoine, Lee Chong, Aesop Cho, Thomas E. Renau, Bonnie Kuo, Vickie Wong, Maria Ludwikow, Negar Garizi, Nadeem Iqbal et al. SummaryPlus | Full Text + Links | PDF (263 K) | |||
|
Biaryl guanidine inhibitors of in vitro HCV-IRES activity • SHORT COMMUNICATION Elizabeth A. Jefferson, Punit P. Seth, Dale E. Robinson, Dana K. Winter, Alycia Miyaji, Stephen A. Osgood, Eric E. Swayze and Lisa M. Risen SummaryPlus | Full Text + Links | PDF (300 K) | |||
|
N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing • SHORT COMMUNICATION Sandra Castang, Bernard Chantegrel, Christian Deshayes, René Dolmazon, Patrice Gouet, Richard Haser, Sylvie Reverchon, William Nasser, Nicole Hugouvieux-Cotte-Pattat and Alain Doutheau SummaryPlus | Full Text + Links | PDF (494 K) | |||
|
Potent and selective proline derived dipeptidyl peptidase IV inhibitors • SHORT COMMUNICATION Scott D. Edmondson, Anthony Mastracchio, Maria Beconi, Lawrence F. Colwell, Jr., Bahanu Habulihaz, Huaibing He, Sanjeev Kumar, Barbara Leiting, Kathryn A. Lyons et al. SummaryPlus | Full Text + Links | PDF (303 K) | |||
|
N- 2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl acetamide: an orally bioavailable melatonin receptor agonist • SHORT COMMUNICATION Li-Qiang Sun, Katherine Takaki, Jie Chen, Lawrence Iben, Jay O. Knipe, Lori Pajor, Cathy D. Mahle, Elaine Ryan and Cen Xu SummaryPlus | Full Text + Links | PDF (273 K) | |||
|
Specificity of human trans-sialidase as probed with gangliosides • SHORT COMMUNICATION E.Yu. Nikonova, V.V. Tertov, C. Sato, K. Kitajima and N.V. Bovin SummaryPlus | Full Text + Links | PDF (285 K) | |||
|
Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa • SHORT COMMUNICATION Sochanchingwung Rumthao, Oukseub Lee, Qi Sheng, WenTao Fu, Debbie C. Mulhearn, David Crich, Andrew D. Mesecar and Michael E. Johnson SummaryPlus | Full Text + Links | PDF (385 K) | |||
|
Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors • SHORT COMMUNICATION Masahiro Tanaka, Shoichi Sagawa, Jun-ichi Hoshi, Fumito Shimoma, Isamu Matsuda, Kenji Sakoda, Tomohiko Sasase, Masanori Shindo and Takashi Inaba SummaryPlus | Full Text + Links | PDF (274 K) | |||
|
Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells • SHORT COMMUNICATION Eun-Jin Lee, Hyun-Jung Lee, Hyen Joo Park, Hye-Young Min, Myung-Eun Suh, Hwa-Jin Chung and Sang Kook Lee SummaryPlus | Full Text + Links | PDF (411 K) | |||
|
Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists • SHORT COMMUNICATION Radhakrishnan Mahesh, Ramachandran Venkatesha Perumal and Pandi Vijaya Pandi SummaryPlus | Full Text + Links | PDF (254 K) | |||
|
Synthesis of 5a-carba-hexopyranoses and hexopyranosylamines, as well as 5a,5a′-dicarbadisaccharides, from 3,8-dioxatricyclo[4.2.1.02,4]nonan-9-ol: glycosidase inhibitory activity of N-substituted 5a-carba-β-gluco- and β-galactopyranosylamines, and derivatives thereof • SHORT COMMUNICATION Seiichiro Ogawa, Sho Funayama, Kensuke Okazaki, Fumito Ishizuka, Yoko Sakata and Fuminao Doi SummaryPlus | Full Text + Links | PDF (306 K) | |||
|
Anticancer activity of 3-O-acyl and alkyl-(−)-epicatechin derivatives • SHORT COMMUNICATION Ki Duk Park, Sul Gi Lee, Sung Uk Kim, Sung Han Kim, Won Suck Sun, Sung Jin Cho and Do Hyeon Jeong SummaryPlus | Full Text + Links | PDF (260 K) | |||
|
Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position • SHORT COMMUNICATION Hiroaki Inagaki, Hisashi Takahashi and Makoto Takemura SummaryPlus | Full Text + Links | PDF (287 K) | |||
|
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands • SHORT COMMUNICATION Nilesh Shah and Thomas S. Scanlan SummaryPlus | Full Text + Links | PDF (354 K) | |||
|
Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential β-cell imaging agent • SHORT COMMUNICATION Björn Wängler, Carmen Beck, Chyng Yann Shiue, Stephan Schneider, Christina Schwanstecher, Mathias Schwanstecher, Peter Johannes Feilen, Abass Alavi, Frank Rösch and Ralf Schirrmacher SummaryPlus | Full Text + Links | PDF (288 K) | |||
|
Synthesis and biological activity of novel antibacterial quinazolines • SHORT COMMUNICATION Preet M.S. Bedi, V. Kumar and Mohinder P. Mahajan SummaryPlus | Full Text + Links | PDF (254 K) | |||
|
Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors • SHORT COMMUNICATION Samir Yahiaoui, Christelle Pouget, Catherine Fagnere, Yves Champavier, Gérard Habrioux and Albert José Chulia SummaryPlus | Full Text + Links | PDF (285 K) | |||
|
Facile incorporation of urea pseudopeptides into protease substrate analogue inhibitors • SHORT COMMUNICATION Adam C. Myers, Jennifer A. Kowalski and Mark A. Lipton SummaryPlus | Full Text + Links | PDF (283 K) | |||
|
Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists • SHORT COMMUNICATION Bo Liu, Gang Liu, Zhili Xin, Micheal D. Serby, Hongyu Zhao, Verlyn G. Schaefer, H. Douglas Falls, Wiweka Kaszubska, Christine A. Collins and Hing L. Sham SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins • SHORT COMMUNICATION Bart L. De Corte, William A. Kinney, Li Liu, Shyamali Ghosh, Livia Brunner, William J. Hoekstra, Rosemary J. Santulli, Robert W. Tuman, Judith Baker, Candace Burns et al. SummaryPlus | Full Text + Links | PDF (320 K) | |||
|
Corrigendum to “Synthesis and biological activity of some known and putative duloxetine metabolites”: [Bioorg. Med. Chem. Lett. 14 (2004) 3481] • ERRATUM F. Kuo, T.A. Gillespie, P. Kulanthaivel, R.J. Lantz, T.W. Ma, D.L.G. Nelson, P.G. Threlkeld, W.J. Wheeler, P. Yi and M. Zmijewski SummaryPlus | Full Text + Links | PDF (203 K) | |||
|
Editorial board • MISCELLANEOUS PDF (391 K) | |||
|
Contributors to this issue • MISCELLANEOUS PDF (188 K) | |||
|
Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
|
|
|
|
|
|
| Copyright © 2004 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V. |
